Assuming it is an 8X 4 sheet (works for any size) then too big for most saws. Use a hand held circular, a batten and a tape measure/ Draw a triangle 4 ft on the side across the sheet and 3 ft along the side. The edge joining the 2 sides is 5ft, , Draw a line across the sheet and if you have measured correctly and teh 3 sides of the triangle are 3,4,5, then your line must be at right angles to the side. Clamp batten to the plywood parallel tp you line to act a st a guide for your saw ( or use a track saw). Once you have 2 sides at 90 degrees it is just measuring to set up you batten and using the saw
I have a large olld scrap pallet that I sue as a base so the saw can cut right through