No trouble with that size even on old systems.
I do (or did, mostly retired) lots of HR work and 'what if' modelling on pay and benefits, and before that was HR head for a biggish employer. Excel enabled a lot of the work we did - proper big databases and systems for running things, excel for 'thinking' with.
Some hints and thoughts:
If you are keeping author records, use 2 columns, surname and first name. Maybe even an honorific which will be blank in most cases, but think SIR ....Conan Doyle. You can always concatenate them, but keeping them separate makes it so much easier to sort and search. As an example, Tate gallery online shop has got its act together now, I emailed them a few months back, but last year if you were shopping for a Hepworth print you would find some listed under H for Hepworth, some under B for Barbara and one under D - for Dame. This wasn't multiple listings of the same thing, you had to look at all 3 to see the complete choice. I was surprised that they had no books on Brancusi, then I found them listed under C - his first name is Constatntin but nobody ever uses it, we don't talks about Pablos, they are PIcassos. Be consistent and get it right from the start, it pays off.
You also need a house rule on indefinite & definite articles at the start of titles. Would you search for "The Book Thief" under B or T? Doesn't matter which way you do it as long as its just one way. Excel is brilliant but its also 'stupid' - inanimate. It doesn't understand that you want to sort things alphabetically and ignore A s and The s.
Backup has been mentioned before. When PCs first started to appear our IT manager wisely said "It's not IF your hard disc fails, it's WHEN it fails." They are a lot more reliable now, but I have always remembered that and backup all that is important. Jack Schofield, wise Guardian tech editor who sadly died last year, always said data doesn't really exist unless it exists in 3 places. My 3 places are the laptop, NAS and Microsoft Onedrive. That might be overkill for you, but have at least one backup.
When I was a student, to correlate 2 sets of variables you had to manually do it - sums of squares etc., if you were lucky you had a comptometer type mechanical calculator to help. 200 experimental results was 2 days tedious work. Now with excel you just highlight the 2 columns of data and choose the correlation you want from the functions - 60 seconds tops.