I find the domino a lot quicker and I think creates a better joint. The spindle moulder/router table option would be a scribed joined and I am not really a fan. If you look at my doors I have a small ovolo moulding on the rails/stiles, I mitre this as part of the rail/stile. Much nicer IMHO plus I don't need lots of scribe sets for different profiles.
This is my order of work for doors, just for interest .
Prepare timber and cut all rails/stiles to length
Domino all joints
Cut the mitres (sliding table over the router table with a 45 deg cutter.
Machine the moulding
Machine the groove for the panel.
Job done.
Over the years I have done all other methods and this I have found ( for me anyway) is the most versatile, strongest and fastest way. (compared to a scribed joint for strength and standard mortice/tenon for speed)