For info radiators have a user operated valve on one end, might be a TRV and a lockshield valve on the other, this is the valve used to balance your rads.
Back to the challenge of optimising the Boiler/radiator performance.
I get the feeling that the condensing boiler would prefer the set up to be static with no variables to affect the performance.
A little knowledge is a dangerous thing but this is what I've gleaned from t'internet 'experts':
Traditionally you open up all the rad valves and find out the order in which they heat up.
Then the rads nearest the boiler and those in the upper stories (heat rises) have their lockshields restricted to a quarter turn open.
This is because the rads that heat up quicker need to reduce the flow through the rad to have min 12c difference between input and output flow to the rad.
Idea is to get some flow to the downstream rads to make sure they don't take ages to heat up and that heat is used to heat the rads and not just returned to the boiler.
Return temp should ideally be 20c less than boiler output temp.
There may be some nuances but I think that's the basic idea.
All work well if everything stays the same, including outside temp and humidity, indoor temperature (and humidity?), Radiator valves are not touched. HW heating doesn't kick in.
So it's better to keep all rads on. TRVs will disrupt the flow because they'll close the valve and push flow to downstream rads, and/or worse still, the boiler.
Turning off rads not needed will affect the balance, dependent on whether they are close to boiler or upstairs.
From my limited understanding it's a tricky problem to solve. There are too many variables that can affect the initial optimisation.
That's why someone came up with a smart pump and also other gadgets to help solve the problems.
https://www.bbc.co.uk/news/business-62900202