I use a Domino for small and medium tenons, and a Domino XL for large tenons.
The real challenge comes with show-off through-tenons, especially as since the Dominos arrived I just don't cut that many tenons any more and my hand saw skills, which were never great, have gone rapidly downhill.
So for the odd prestige through-tenon I cut the mortice with a powered morticer (working all the way through with the face against the fence and a sacrificial back-up piece underneath), I cut all the way through to avoid the tiny "step" that often happens when working from each side of a through-mortice towards the middle.
With the mortice complete I then use the David Charlesworth method of tenoning, which is to make a hand planed false loose tenon and insert that into the mortice giving the precise fit I want, then use this to calibrate the height of a dado set, router bit, or spindle cutter to gradually remove the tenon waste.
It's a big old faff, but it's pretty much bullet proof.