You need to be a bit more specific: what _exactly_ are you trying to do, in what wood, with/without glue, and what are the dimensions involved? Even then, the best thing is to get the correct screws (length and thread style) and experiment. long-to-long grain and end-to-long grain will have different strengths.
If you are using "proper" pocket hole screws, there are several types of screwthread, depending o the application. I use Kreg screws*, and they sell at least two types, for hardwood and softwood, and I think a third for man-made boards (MDF, chipboards, etc.). On the occasions when I have used the wrong sort, results have not been satisfactory. There are also different lengths depending on stock dimensions.
If you are using them simply to hold work together for glueing, as Jerome suggests, you have a bit more leeway, but the glue faces will be pulled out of alignment by the pocket screws, so you need to clamp the joint flat before starting. I have tried to manage without doing this (as seen in umpteen YouTube videos) - that way lies madness and a bulging scrap bin.
Over to you...
*because I like them! Other sorts are probably just as good.