As you will have now seen from Alex Snodgrass's video, narrow blades should be centred at the deepest part of the tooth gullet. However, as the blade width increases, this will not be possible and with some older model bandsaws, some have blade teeth off the edge of the wheel.
The most important thing is to ensure that the blade runs in the same place and is always vertical from the side view, using a set square as well as from the front view. As long as that can be maintained, BEFORE THE GUIDES ARE POSITIONED, you will get a straight cut. The guides are then positioned, but not before the blade is stable.
On the 1/8" blades that I regularly use, I have 14tpi, but the 1/2" sabrecut has only 3tpi
When using fine blades, the greater number of teeth will give you a smoother cut and if you need to know more about what is best, then try and speak with the Tuffsaw boss, Ian John, who knows it all.